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Part 2: The 5 Pillars of Androgen Sensitivity

Part 2: The 5 Pillars of Androgen Sensitivity

How DHT, Estrogen, Thyroid, and IGF-1 Determine Whether Your Testosterone Works or Not

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Hans
May 02, 2025
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Part 2: The 5 Pillars of Androgen Sensitivity
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You can have high testosterone on paper.
But if your body isn’t listening, it’s not doing much for you.

That’s where androgen sensitivity comes in—and at the center of it is the androgen receptor (AR). If your receptors are weak, inflamed, or downregulated, testosterone becomes background noise.

In this part, we’ll cover the 5 core biological systems that determine whether your testosterone signal gets heard—or ignored.

Here’s part 1 if you haven’t checked it out yet.

High Testosterone Means Nothing Without Sensitivity (Part 1)

Hans
·
May 2
High Testosterone Means Nothing Without Sensitivity (Part 1)

Preface (why I’m writing this series)

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In the rest of this article, I talk about the top things that increase or decrease androgen sensitivity and the best supplements (with links and dose recommendations) on how to optimize them.

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